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So far, the dynamic transcriptional signatures at distinct pathogenic stages early after SE in the CA region have not been examined. Here, we aimed to elucidate the transcriptional cascades triggered shortly after SE and the key transcription factors (TFs) mediating these changes. Hereby, CA1 is of particular importance as it constitutes the output point of the hippocampal tri-synaptic circuit. Only a few days after SE, the hippocampal CA1 subfield acquires the properties of an epileptogenic focus 10.Ĭurrently, it is believed that SE as a transient insult induces a specific transcriptional program that differs between distinct hippocampal subregions. CA1 represents a key anatomo-functional compartment of the tri-synaptic pathway under epileptogenic conditions 9. In experimental TLE models, including those triggered by kainic acid and pilocarpine-induced status epilepticus (SE), the hippocampal CA1 region appears to be an important site of epileptogenesis 6, 7, 8. Recent data suggest that SE induces highly variable gene expression in different cell types and compartments of the hippocampus 3, 4, 5. Temporal lobe epilepsy (TLE) is the most common form of focal epilepsy, which is often pharmacoresistant to antiseizure medication. It involves the transition of a stable brain network into a functionally altered structure that leads to the development of spontaneously recurring seizures 2. Similar content being viewed by othersĮpileptogenesis is the process by which changes occur in the brain after a precipitating injury or insult that leads to the development of epilepsy 1. Transcription factors mediating this transcriptomic switch represent targets for new highly selected, cell type and time window-specific anti-epileptogenic strategies. CA1 quickly responds to SE by inducing transcription of genes linked to inflammation and excitation stress. Binding sites for the transcription factors Nfkb1, Spi1, Irf8, and two Runx family members, were enriched within promoters of differentially expressed genes related to major inflammatory processes, whereas the transcriptional repressors Suz12, Nfe2l2 and Rest were associated with hyperexcitability and GABA / glutamate receptor activity. Major differentially expressed mRNAs encoded primarily immediate early and excitability-related gene products, as well as genes encoding immune signalling factors. Robust transcriptomic changes were detected at 6 h after SE and at subsequent time points during early epileptogenesis. Bioinformatics was used to decipher altered gene expression, signalling cascades and their corresponding cell type profiles. RNA sequencing of CA1 was performed in the mouse pilocarpine-induced SE model at multiple time points ranging from 6 to 72 h after the initial insult. Here, we aimed to elucidate the early SE-elicited mRNA signature changes and the respective upstream regulatory cascades in CA1. The transcriptional profiles of the distinct hippocampal neurons are highly dynamic during epileptogenesis. A key role in epileptogenesis has been attributed to the CA1 region as the last relay station in the hippocampal circuit and as site of aberrant plasticity, e.g. As a consequence, the entire tri-synaptic circuit of the hippocampus is fundamentally impaired. Transient brain insults including status epilepticus (SE) can initiate a process termed ‘epileptogenesis’ that results in chronic temporal lobe epilepsy. The XZ Premium will need to wait for the Snapdragon 835 SoC to become available, so it will not go on sale until later in the spring. The XZs will be available at select retailers, including Amazon and Best Buy, on April 5 for $699.99 (64GB). The Xperia XZ Premium comes in two colors-Luminous Chrome and Deepsea Black-while the Xperia XZs offers three color options-Ice Blue, Warm Silver, and Black. There’s also predictive hybrid autofocus that combines motion tracking and a motion prediction engine to lock onto an object and keep it in focus as it moves around. The Predictive Capture feature starts buffering images when the camera detects motion, helping you capture fleeting moments you may have otherwise missed by allowing you to select from four photos taken up to 2 seconds before the shutter button was pressed. This means the Motion Eye cameras can capture super slow-motion video at an amazing 960fps (most phones are still stuck at 120fps or at most 240fps). Both sensors are from Sony of course and are an integral part of the new Motion Eye camera system that incorporates technology from Sony’s a-series and Cyber-shot cameras, enabling 5x faster image scanning from the sensor. Storage can be expanded on all models with a microSD card.īoth new XZ models use a similar camera configuration with a 13MP sensor behind an f/2.0 lens on the front and a 19MP sensor on the back. The dual SIM XZs comes with 64GB of internal storage like the XZ Premium, but the single SIM version only comes with 32GB. It looks like both will have single and dual SIM versions. They also have an IP68 dust and water resistance rating, a feature Sony fans have grown accustomed to. In addition to 4GB of RAM, both phones also share some nice audio features, including support for high-resolution audio and stereo front-facing speakers. Xperia XZ Premium (left), Xperia XZs (right) Both phones at least support Qualcomm Quick Charge 3.0 fast charging. Based solely on this information, I’m a little concerned about battery life, but we’ll have to wait until devices start shipping to see how long they last. A smaller chassis means an even smaller battery for the XZs at 2900 mAh. Sealed inside the XZ Premium is 3230 mAh battery, which is a little smaller than I would like to see for a 5.5-inch class phone with a high-resolution 4K display. Both displays support Sony’s X-Reality picture engine and Dynamic Contrast Enhancement technology. The XZs puts a 5.2-inch 1080p TRILUMINOS display into a smaller chassis. It will be interesting to see if the display runs at 4K all the time or just when watching 4K content, scaling back to 1080p otherwise. The XZ Premium is the larger of the two with a 5.5-inch TRILUMINOS display, which is notable for being the first panel to combine 4K resolution with HDR image support. QC 3.0 fast charging, IP68 environment protection, high-resolution audio, stereo front-facing speakers The XZs will use the previous generation Snapdragon 820, which uses four fully-custom Kryo CPU cores. For starters, the XZ Premium will use Qualcomm’s latest Snapdragon 835 SoC, the first to use semi-custom ARM CPU cores and the first SoC available on Samsung’s new 10nm process. There are a few significant differences between the new Xperias. They also have an aluminum frame sandwiched between front and rear Gorilla glass panels. Both models employ classic Sony styling-a rectangular shape with rounded sides and a flat top and bottom. Sony announced today at MWC 2017 that it’s bringing two new premium phones to the US market: the Xperia XZ Premium and Xperia XZs. Plus the film’s title is a reference to where it was originally going to be set, the City of Light, Paris. His love-inspired quest and the great lengths he goes to achieve his goal is definitely in the same interests as Jeunet’s heroine, though its monochrome appearance is opposite to Amélie’s the intense hues. The sames of City Lights and Amélie are fairly strong – both feature a supremely naïve and idealistic hero, with secondary personality traits of being shy, fearless and almost mute, it would be no surprise if some of Amélie’s quirk was filtered through the silent pantomime of Chaplin’s Little Tramp. The choreography in the film’s most celebrated boxing match sequence is hypnotically hysterical, an almost-dance of stumbling, fooling, tripping, punching and deception. This fairly threadbare plot is just framework for a collection of short comic sketches featuring a suicidal millionaire, whistling hiccups and a drunken night on the town. The heart-warming tale of Chaplin’s Little Tramp after having fallen in love with a blind flower girl, pretends to be affluent and sets out to earn the money for her rent and possible sight-saving eye surgery. One would say that his style is cartoonish, but it must be noted that some of the best of Chaplin’s work was created before the first cartoons – cartoons are Chaplin-esque.Ĭity Lights is arguably Chaplin’s greatest achievement as actor and director. His energetic slapstick performances are nothing like the comedies of today – it is often criticized that classic Hollywood cinema is slow, which is not the case with Chaplin, able to fit jokes in at a lightning stacked pace, a mere exaggerated reaction take enough to illicit tears of laughter. It was once said of Jim Carrey: “He can make you laugh with no more than the frantic flailing of his limbs”, and although his prowess as a physical comedian is impressive, it is nothing compared to the master, Charlie Chaplin. This list of films has been compiled in a vein attempt to recommend those that share some of these aspects, but as we all know – there is no one quite like Amélie. More than anything though its quirks are grounded by an over-arcing theme of wanting to love and be loved, which in turn creates a warm feeling like no other.Īmélie is a comfort blanket for when the world is not quite okay, where the greatest antagonist is a beastly greengrocer. There are certain things that make Amélie the unique vision that is: its stylish, candy-coloured palette, Tautou’s child-like wonder and her intangible likeability as an actress, its twee quests and mysteries, scatterings of magic realism and post-modernism, as well as Yann Tiersen’s swooning soundtrack. Tautou, not wanting to be typecast her entire career, quickly sort not to replicate herself seeking roles as schemers (Priceless), plucky immigrants (Dirty Pretty Things) and a Sexy Lamp for Tom Hanks to talk to in mindless Hollywood fare (The Da Vinci Code). Jeunet’s work post-2001 cannot help but pale in comparison to his fizzy, life-affirming magnum opus. The problem with Amélie’s unique-ness is that there are no films that are truly comparable – Jeunet’s preceding films (Delicatessen, The City of Lost Children and Alien: Resurrection) toy with darker themes and, though masterpieces in their own right (apart from Alien: Resurrection, which is just really bad), are not as accessible or light-hearted as Amélie. She gains a certain enjoyment from cracking the top of a brûlée with a spoon, skimming stones, and giving inanimate objects holidays the actress that brings this iconic creation to life is the lovely Audrey Tautou. The simple yet engrossing tale of a naïve French girl who acts as the personification of karma and deals out justified retribution to the evil and childhood memories to the good. Rarely is a film as life-affirming and singular as Jean-Pierre Jeunet’s La fabuleux destin d’Amélie Poulain (or as it is known in the English speaking world: Amélie). In addition, the plan was to make extensive use of synthetic materials and modern manufacturing technologies, which led to the Glock 17 becoming a cost-effective candidate. Within three months, Glock had developed a working prototype that combined proven mechanisms and traits from previous pistol designs. Glock became aware of the Austrian Army's planned procurement, and in 1982, assembled a team of Europe's leading handgun experts from military, police, and civilian sport-shooting circles to define the most desirable characteristics in a combat pistol. The normal maximum operating pressure (P max) for the 9 mm NATO is 2,520 bar (252 MPa 36,500 psi). The pistol was to then be used to fire an overpressure test cartridge generating 5,000 bar (500 MPa 73,000 psi). After firing 15,000 rounds of standard ammunition, the pistol was to be inspected for wear. The Federal Ministry of Defence of Austria formulated a list of 17 criteria for the new generation service pistol, including requirements that it would be self loading fire the NATO-standard 9×19mm Parabellum round the magazines were not to require any means of assistance for loading be secure against accidental discharge from shock, strike, and drop from a height of 2 m (6 ft 7 in) onto a steel plate. In 1980, the Austrian Armed Forces announced that it would seek tenders for a new, modern duty pistol to replace their World War II–era Walther P38 handguns. Glock introduced ferritic nitrocarburizing into the firearms industry as an anticorrosion surface treatment for metal gun parts. Glock had extensive experience in advanced synthetic polymers, which was instrumental in the company's design of the first commercially successful line of pistols with a polymer frame. The company's founder and head engineer, Gaston Glock, had no experience with firearms design or manufacture at the time their first pistol, the Glock 17, was being prototyped. Glocks are also popular firearms among civilians for recreational and competition shooting, home- and self-defense, both in concealed or open carry. Glock pistols have become the company's most profitable line of products, and have been supplied to national armed forces, security agencies, and police forces in at least 48 countries. The firearm entered Austrian military and police service by 1982 after becoming the top performer in reliability and safety tests. Glock (stylized as GLOCK) is a brand of polymer- framed, short recoil-operated, locked-breech semi-automatic pistols designed and produced by Austrian manufacturer Glock Ges.m.b.H. Short recoil, locked breech, tilting barrel ( straight blowback for Glock 25, 28 and 44) Invoice > Items > Items > Item Line Number The Supplier Purchase Listing Total table shows the total purchase and VAT amounts of the supplier purchase listings in Arab Emirate Dirham.Ĭustomer > Primary Information > Company Name Value of VAT in foreign currency(if applicable) Value of purchase excluding VAT in foreign currency(if applicable) ISO 4217 currency codes of foreign currency Value of purchase excluding VAT in Arab Emirate Dirhamīill > Expenses and Items > Items > Amountīill > Expenses and Items > Expenses > Amountīill > Expenses and Items > Items > VAT Amtīill > Expenses and Items > Expenses > VAT Amt Vendor > Address list > Country (billing address)Īny reference ID identifying the transactionīill > Expenses and Items > Expenses > Expense Line Numberīill > Expenses and Items > Items > Item Line Numberīill > Expenses and Items > Expenses > Account Vendor > Primary Information > Company NameĬountry of the supplier (Emirate if Country is UAE)īill > Expenses and Items > Expenses > Emirateīill > Expenses and Items > Items > Emirate The Supplier Purchase Listing Table consists of information relevant to the supplier, and associated details for source documents such as purchase invoices, imports, credit notes, and payments. Reports > TAX > Audit Files > UAE FAF > Audit Files > Date Created Reports > TAX > Audit Files > UAE FAF > To Reports > TAX > Audit Files > UAE FAF > Period Name of the tax agent in case filing is done by a tax agent Name of the tax agency in case filing is done by a tax agency To set up statutory chart of account names and numbers, see Statutory Chart of Accounts for Tax Audit Files.Ĭompany or Subsidiary > VAT Registration No. The parent company requires a subsidiary to use account names and numbers that are not in the formats required for statutory compliance in the subsidiary’s country. The standard chart of accounts is shared with other subsidiaries Use the statutory chart of accounts in the following situations: For more information, see Chart of Accounts Management.įor NetSuite OneWorld, use the statutory chart of accounts if the standard chart of accounts does not comply with regulatory requirements. To set up your chart of accounts, go to Setup > Accounting > Manage G/L > Chart of Accounts. Use the standard chart of accounts in NetSuite. On the General subtab, check the Use Account Numbers box.įor more information, see General Accounting Preferences. Go to Setup > Accounting > Preferences > Accounting Preferences. Prerequisites to Generate the UAE FAF Reportīefore you can successfully generate the UAE FAF report, you must first complete the following tasks: The file is based on general ledger chart of accounts entries, master file data for customers and suppliers, and details of invoices, payments, and adjustments. The FTA VAT Audit File, also known as FAF, is an export of accounting entries in comma separated values (CSV) file format specified by the FTA. As part of the audit process, business are required to provide accounting information to validate their submitted tax declarations. The United Arab Emirates tax authority, Federal Tax Authority (FTA), audits businesses at its discretion to ensure accurate and timely tax declarations. This website needs an updated browser to run properly. Write us at are eager to start collaborations for future projects, not only regarding literature but also educational tools in general, for every kind of users. This website and the printed version have to be considered as a work in progress, which will be improved through the support from the users as well as scholars and literary critics.įor this reason, whether you are a student, a teacher, an expert of stil novo literature, a cartographer, if you want to help us to improve these tools we encourage you to leave us your feedback, regarding literary errors, features, improvement advices. The syntax, the rhythm, the lexicon used by Longfellow may feel odd for native english speakers, but they render the original language with great accuracy.Īs in the Italian version, we provided links to the Wikipedia descriptions of the Cantos or the characters, but we noticed that for this subject the English Wikipedia is less reliable and precise than the Italian one, so use it with caution and read the original text!Ī special thanks to Maura Dalai, literary translator, for helping us revising and translating the texts. We chose the Longfellow translation not only because it's open source, but also for its closeness to the language of Dante. The whole text is available on Wikisource and it's in the public domain. The translation to the English language is based on the one provided by Henry Wadsworth Longfellow. The project won the Grand Prix and the Gold prize for Didactics at IIID Awards 2017, by the International Institute of Information Design. The work is based on the anthology "Testi e scenari" - Volume 1 (Panebianco, Pisoni, Reggiani, Malpensa), published by Zanichelli in 2009, and it has been developed by Alpaca together with the Molotro design studio. The printed version and this digital version of the Dante's Inferno have been developed to be a synsemic access point to Dante's literature, aiding its study. Transfer of Knowledge and Design of Didactic Tools> is freely available at. The research article The Project “Interactive Topography of Dante’s Inferno”. We have released an update to this website ( version 2.0, Italian language only and non responsive, at the moment), available at, which has been developed starting from the results of the usability testing and didactic analysis conducted on secondary school students and teachers in training and in service. The illustrated and interactive Dante's Inferno provides an alternative mode of access to the Divine Comedy first Cantica, a complex text relying on an evident topographical structure. They’re all here.Hotwife! 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The series will continue to feature Jana, the heroine and it will be co-written by Doug Murray and drawn by Jack Jadson. Jana returned with more action and enthusiasm than ever before and the artwork in the book continued to be mind boggling and pure entertainment for readers.Ĭho continued working on Jungle Girl with the announcement of a third series with Dynamite Entertainment. This was all cleared up in 2015, when Cho reappeared with the intentions of finally creating the final season and providing readers with the information they pined for. Cho has promised to unveil her origin in a third season, but after the 2009 second season, there was no further word on a new book or season. Still, readers have no idea of the origin of Jana and they continue to read of her adventures with prehistoric animals and the threats of the island.Īfter the release of the second season, Jana seemed to have disappeared, leaving many unanswered questions for readers. Throughout the season, Jana delivers action and excitement as well as visual appeal, appearing as a sexy saviour. In the second season, the action picks up from the cliff-hanger of season one, with Jana and the survivors dealing with the invasion of the space shuttle. Jana lives on with the saved members of the group, soon seeing a tear drop in the sky, which turns out to be a space shuttle coming towards them. Jana successfully saves the people, but the dangers of the island later claim many lives. Many of the passengers of the plane were drug smugglers, which created the wrath of the other tribe. He once again stated that he would finish the series, but this did not happen until quite a few years later.ĭuring the first season, Jana witnesses a plane crash and saves occupants from two men belonging to another tribe. When the series ended after season 2, readers were unfulfilled and had many questions for Cho regarding the character. However, Cho stated that he would reveal the original of Jana in the third season. Jungle Girl only had 12 issues and ended in 2009. As FRANK Cho was working, he marked his series 1-3, similar to how television marks various series. Join Sheena as she thwarts a monkey-suited villain masquerading as a supernatural being watch Rulah, Jungle Goddess, save the native population from an erupting volcano and see Cave Girl prevent a crew of skull-masked submariners from raiding a village for. The series has been created by Frank Cho, James Murray and Adriano Batista. Jungle Girls reprints fourteen Golden Age stories, each showcasing a different heroine. Jana is the main character in the Jungle Girl comic and she shares similar origins to the Hanna-Barbera’s character. Jungle Girl is one of the top rated comic series offered today and there is a great resemblance to the cartoon Jana of the Jungle. Despite being the major fourteenth release of macOS, High Sierra isn’t much of a transformation, at least on the first look. The Mac must also be using macOS High Sierra or later, the latest version of macOS Sierra or the latest version of OS X El Capitan. Announced at WWDC 2017 in July, the long-awaited macOS High Sierra is now available for the public It means all Mac devices that are compatible can download and install this version of macOS. To download an installer suitable for creating a bootable installer, use the App Store or use a web browser to download from a compatible Mac. Follow the onscreen installation instructions.Ī bootable installer can be useful if you want to install macOS on multiple computers without downloading the installer each time, or when you can't install using the other methods. Open your Applications folder and double-click the macOS installer, named Install. pkg file, then follow the onscreen instructions to install the macOS installer into your Applications folder. Once macOS loads (You might need to select a language first.), click on Utilities > Disk Utility. Release when you see a list of bootable volumes, select the USB stick that you created, and click on the upward-pointing arrow. dmg file to open it and see the package (.pkg) file within.ĭouble-click the. Intel-powered Mac: Press and hold Option (Alt) as you turn your Mac on. Incidentally, you can still find the macOS software on the Mac App Store.Use these links to download a macOS disk image (.dmg) file.ĭouble-click the. One of the benefits of this is that your Mac can be set to automatically download the latest updates and install them, keeping your Mac up-to-date with minimum effort on your part. Now operating system updates come in via Software Updates which is either located in System Settings > General > Software Update or in System Preferences > Software Update (pre-Ventura). However, that changed with Mojave, which arrived in 2018. Since the arrival of the Mac App Store in 2011 (as an update to Snow Leopard) versions of Mac OS X and macOS have been available to download via the Mac App Store. Very old versions of Mac OS X came on a disk and any security updates came via Software Update. If you want to update your Mac to a newer version of macOS the method will be determined by the version of macOS you are running. It’s easy to find out which version of macOS is running on a Mac.įoundry How to install the latest version of macOS If you need to know the build number as well, click the version number to see it. The window that opens might look different from the example shown here, but it always includes the macOS name followed by its version number. If you want to install the latest beta of macOS read about joining Apple’s beta program. From the Apple menu in the upper-left corner of your screen, choose About This Mac. You can install a beta version of Sonoma and test new features that haven’t yet launched. We have a full list of which Macs run which versions of macOS here. macOS 14: Sonoma (Sunburst) – Novem(Latest: 14.1.1).macOS 13: Ventura (Rome) – Novem(Latest: 13.6.2).macOS 12: Monterey (Star) – Octo(Latest: 12.7).macOS 11: Big Sur (GoldenGate) – Novem(Latest: 11.7.10). OS X 10.11: El Capitan (Gala) – Septem(Latest: 10.11.6) Telestream ScreenFlow is award-winning, powerful video editing and screen recording software for Mac that lets you create high-quality software or iPhone.The window that opens may look different from the example shown here, but it always includes the macOS name followed by its version number. OS X 10.9 Mavericks (Cabernet) – Octo(Latest: 10.9.5) From the Apple menu in the upper-left corner of your screen, choose About This Mac.OS X 10.8 Mountain Lion (Zinfandel) – J(Latest: 10.8.5).OS X 10.4.4 Tiger (Chardonnay) – Janu(for Intel Macs) (Latest: 10.4.11).This article will discuss where to download and access installers for MacOS Sonoma 14, macOS Ventura 13, MacOS Monterey 12, macOS Big Sur 11, macOS Catalina, MacOS Mojave, MacOS High Sierra, macOS Sierra, Mac OS X El Capitan, OS X Yosemite, OS X Mavericks. OS X 10 beta: Kodiak – September 13, 2000 Downloading and using different Mac OS installers is very common for troubleshooting purposes, for IT staff and admins, and for tinkerers. |
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